Natural changes in metabolic responses to exercise over the menstrual cycle. Nutritional, Metabolic, Endocrine
Conditions
Interventions
A single-centre observational study where the metabolic responses to exercise will be measured in healthy female participants at 4 weekly timepoints throughout their menstrual cycle.
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Sponsors
University of Nottingham
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Female 2. Age 18 - 35 years 3. Regular menstrual cycle (every 25 - 38 days) 4. Nulliparous 5. Habitual exercise - 45 minutes of moderate exercise (brisk walking or jogging), minimum 3 days per week
Exclusion criteria
Exclusion criteria: 1. A history of smoking or chronic diseases 2. Use of oral contraceptives or other hormone medications for at least 6 months prior 3. Pregnancy or lactation 4. Pearning difficulties or cognitive impairments or social problems or substance abuse, or mental illness, which would make it difficult to complete the protocol
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Exercise-induced changes in liver glycogen concentrations (difference between before and after 45-minute cycle exercise) measured using 13C Magnetic Resonance Spectroscopy (MRS) on 4 separate occasions, one week apart. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Exercise-induced changes in muscle glycogen concentrations (difference between before and after 45-minute cycle exercise) measured using 13C MRS at 4 separate occasions, one week apart. 2. Blood metabolites (glucose, lactate, lipids) and hormones (estradiol, progesterone, luteinizing hormone and follicular stimulating hormone) measured before and after a 45-minute cycle exercise using blood assays on 4 separate occasions, one week apart. | — |
Countries
England, United Kingdom
Contacts
Public ContactHenry Bowler
Outcome results
None listed