Low mood / depression Mental and Behavioural Disorders Depressive episode
Conditions
Interventions
Emotion Recognition Training (ERT):
Session 1: The first session will involve a screening assessment to ensure that participants fit the requirements of the study and are in general go
this will last approximately 5 minutes and participants will just lie still. In the second part of the MRI scan participants will view images projected on a screen above their head. This session would
Sponsors
University of Bristol (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged between 18 and 40 years 2. Participants who score 14 or higher on the Beck Depression Inventory (BDI)-II 3. English as first language or equivalent level of fluency 4. Right-handed (as assessed by Edinburgh Handedness Inventory) 5. Able to give informed consent as judged by lead researcher
Exclusion criteria
Exclusion criteria: 1. Primary anxiety disorder, psychosis, bipolar disorder or substance dependence [other than nicotine and caffeine] as defined by Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) 2. Current use of illicit drug (except cannabis) 3. Being at clinically significant risk for suicidal behaviour 4. Use of psychotropic medication in last 5 weeks prior to study 5. Major somatic or neurological disorders and concurrent medication which could alter emotional processing (including active treatment with counselling, cognitive behavioural therapy or other psychotherapies). We will allow intermittent use of medication, judged by the principal investigator. 7. Participants who have contra-indication for magnetic resonance imaging (MRI) imaging 8. Participants unable to tolerate the scanner environment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Neural response to emotional cues: Blood oxygen level dependent (BOLD) responses to emotional facial expression at baseline and one week. | — |
Secondary
| Measure | Time frame |
|---|---|
| Current secondary outcome measures as of 17/05/2013: 1. Depressive symptoms: Beck Depression Inventory-ii (BDI-ii) at baseline and one week 2. Depressive symptoms: Hamilton Rating Scale for Depression (HAM-D) at baseline and one week 3. Anxiety symptoms: Beck Anxiety Inventory (BAI) at baseline and one week 4. Positive affect: Positive and Negative Affect Schedule (PANAS?) at one week 5. Negative affect: Positive and Negative Affect Schedule (PANAS?) at one week 6. Emotion sensitivity: Emotion Recognition Task (ERT) at one week 7. Approach motivation and persistence: The Fishing Game at one week 8. Depressive interpretation bias: The Scrambled Sentences Test (SST) at one week Previous secondary outcome measures until 17/05/2013: 1. Depressive symptoms: Hamilton Rating Scale for Depression (HAM-D) 2. Anxiety symptoms: Beck Anxiety Inventory (BAI) (rated over the past week) 3. Positive affect: Positive and Negative Affect Schedule (PANAS) (rated over the past day) 4. Negative affect: Positive and Negative Affect Schedule (PANAS) (rated over the past day) | — |
Countries
United Kingdom
Outcome results
None listed