Coronary artery disease patients with obstructive or central sleep apnea Circulatory System
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: Men and women 18-80 yrs of age with coronary artery disease (defined as a documented myocardial infarction, coronary bypass surgery or coronary angioplasty and/or stenting) and obstructive or central sleep apnea (AHI greater than 15 events/hr)
Exclusion criteria
Exclusion criteria: 1. Angina 2. Use of diuretics 3. Adeno-tonsillar hypertrophy 4. Inability to walk due to orthopedic or musculoskeletal problems 5. Previously treated OSA 6. Patients exercising more than 150 minutes per week at moderate intensity
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Apnea hypopnea index, measured by polysomnogram at baseline and 4-weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Leg fluid volume measured by bio-electrical impendence 2. Overnight changes in leg fluid volume, thoracic fluid volume, neck circumference and neck fluid volume measured by bio-electrical impendence 3. Upper-airway cross-sectional area measured by acoustic pharyngometry | — |
Countries
Canada