CArdiac Death kidney Machine Perfusion trial

A multicentre randomised controlled study of machine perfusion on cardiac death donor kidneys

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN50082383

Enrollment

270

Registered

2011-09-06

Start date

2011-04-06

Completion date

Unknown

Last updated

2019-01-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Kidney transplantion Surgery Renal failure

Interventions

One kidney will be placed upon the LifePort pulsatile perfusion machine. The other will be placed in standard cold-storage ice-box

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients who receive a kidney transplant from a controlled or uncontrolled cardiac-death deceased donor 2. Recipient over the age of 18

Exclusion criteria

Exclusion criteria: 1. Lack of informed consent 2. Positive crossmatch 3. Previous recipient of non-kidney solid-organ transplant

Design outcomes

Primary

Measure	Time frame
Delayed graft function - the need for dialysis within the first week following transplantation	—

Secondary

Measure	Time frame
1. Duration of delayed graft function 2. The area under the curve of the daily serum creatinine level at days 1 to 14 3. Day 14 calculated estimated Glomerular Filtration Rate (eGFR) [abbreviated Modified Diet in Renal Disease (MDRD) technique] 4. The need for dialysis in the first 7 days excluding the first 24 hours post transplant 5. Median times to last dialysis 6. Non-graft function rates, defined as a kidney transplant that fails to provide one month of dialysis free renal replacement, where loss is not attributable directly to rejection or vascular thrombosis 7. Incidence of acute rejection 8. Three and twelve month graft survival 9. Three and twelve month serum creatinine 10. Three and twelve month glomerular filtration rate (MDRD method18) 11. Incidence of graft loss for technical reasons, e.g. renal artery or vein thrombosis 12. One year patient survival 13. Length of hospital stay	—

Measure

Time frame

1. Duration of delayed graft function 2. The area under the curve of the daily serum creatinine level at days 1 to 14 3. Day 14 calculated estimated Glomerular Filtration Rate (eGFR) [abbreviated Modified Diet in Renal Disease (MDRD) technique] 4. The need for dialysis in the first 7 days excluding the first 24 hours post transplant 5. Median times to last dialysis 6. Non-graft function rates, defined as a kidney transplant that fails to provide one month of dialysis free renal replacement, where loss is not attributable directly to rejection or vascular thrombosis 7. Incidence of acute rejection 8. Three and twelve month graft survival 9. Three and twelve month serum creatinine 10. Three and twelve month glomerular filtration rate (MDRD method18) 11. Incidence of graft loss for technical reasons, e.g. renal artery or vein thrombosis 12. One year patient survival 13. Length of hospital stay

—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026