Do the remaining insulin-producing cells in people with type 1 diabetes help to maintain good glucose control after exercise?

The role of residual beta-cell function on post-exercise glycaemic variability in individuals with type 1 diabetes

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN50072340

Enrollment

Registered

2019-05-24

Start date

2016-10-01

Completion date

Unknown

Last updated

2023-06-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 1 diabetes Nutritional, Metabolic, Endocrine

Interventions

Patients with Type 1 diabetes with a wide range of residual beta-cell function (from negative to clinically significant) will be recruited. Participants will be identified using urinary C-peptide Crea

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Aged 18-65 years old 2. Clinically diagnosed Type 1 diabetes 3. Treated with exogenous insulin (pump or injection) 4. Free from diabetes complications

Exclusion criteria

Exclusion criteria: 1. Type 1 diabetes participants duration of disease less than 1 year 2. HbA1c > 10% (86 mmol/mol) 3. Unable to complete maximal exercise test

Design outcomes

Primary

Measure	Time frame
The amount of time interstitial glucose is spent in euglycaemia measured using blinded interstitial continuous glucose monitoring	—

Secondary

Measure	Time frame
1. Glycaemic variability (SD, CV%, MAGE, J-Index, CONGA, MAG, M-value) 2. Time spent: hypoglycaemic (10mmol/L, >13.9mmol/L, >16.7mmol/L) 3. Hypoglycaemia stage 1 (10mmol for 15+ minutes) and level 2 (>13.9mmol for 15+ minutes) 4. Corrective bolus/carbohydrate intake	—

Countries

England, United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026