Non-complicated severe acute malnutrition among children 6-59 months. Nutritional, Metabolic, Endocrine
Conditions
Interventions
The intervention tested is restricted to the nutritional treatment of malnourished children involving ready-to use therapeutic foods (RUTFs). The nutritional treatment protocol will be different betwe
Sponsors
ACF France
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Children aged 6 to 59 months 2. Diagnosed with uncomplicated SAM and eligible for CMAM treatment, defined as WHZ <-3 and/or MUAC <115mm 3. No pitting bilateral oedema 4. No medical complications 5. Passed a standardized appetite test
Exclusion criteria
Exclusion criteria: 1. Severe anaemia defined as haemoglobin concentration < 4g/dl 2. Plans to leave the catchment area within the next 6 months 3. Known peanut and/or milk allergy 4. Treatment for SAM already received within the last 6 months, including re-admissions after defaulting, relapses, and medical transfers 5. Malformations or handicap which may affect food intake such as cleft palate, cerebral palsy or Down’s syndrome
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Childrens rate of weight gain (g/kg/d) during treatment, measured at admission, upon weekly visits, and at discharge. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Duration of treatment (days) until recovery 2. Recovery rate, defaulter rate, mortality rate and transfer to hospital rate, measured monthly 3. Growth velocity and change in anthropometry (weight for height, height for age, weight for age, Mid Upper Arm Circumference), measured on a weekly basis from admission to discharge, and with monthly follow-up measurements during 4 months 4. Relapse rate 4 months after discharge 5. Cost-effectiveness ratio of the intervention to rehabilitate one child 6. Average energy intake (kcal/d) of the child during treatment week number 4 7. Level of vitamin A, iron and inflammation markers in the blood, measured at admission and discharge dates 8. Body composition status at admission and discharge, measuring bio-impedancemetry 9. Level of leptin in the blood, measured at admission, and discharge 10. Catabolism markers in hair, measured at admission, and last follow-up 4 months after discharge | — |
Countries
Burkina Faso
Contacts
Public ContactCécile Salpéteur
Outcome results
None listed