Effects of probiotics on liver function in chronic liver disease

Effects of probiotics on liver function in chronic liver disease: a randomised controlled trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN50009946

Enrollment

Registered

2009-11-11

Start date

2009-10-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cirrhosis Digestive System Cirrhosis

Interventions

Oral probiotic or placebo therapy for 30 days

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients aged between 18 and 70 years (either sex) with established cirrhosis 2. No antibiotic or lactulose therapy within 6 weeks 3. No prior use of probiotic therapy

Exclusion criteria

Exclusion criteria: 1. Age under 18 years or over 70 years 2. Antibiotic or lactulose therapy within 6 weeks 3. Prior use of probiotic therapy 4. Hepatocellular carcinoma

Design outcomes

Primary

Measure	Time frame
Markers of liver function, measured at day 7, day 28 and day 56.	—

Secondary

Measure	Time frame
Tolerability, measured at day 7, day 28 and day 56.	—

Countries

Australia

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026