Topic: Cardiovascular
Conditions
Interventions
1. Intervention 1: Cyclosporin A at dose of 2.5 mg/kg
diluted in 100 ml of normal saline. Once only dose given over 30 minutes prior to surgery.
2. Intervention 2: Atorvastatin at a dose of 160 mg
given on the morning of surgery and a second dose of 160 mg repeated 24 hours later
3. Intervention 3: Erythropoietin at a dose of 50,000 IU
given as an infusion of 50 ml over 30 minutes prior to revascularisation. A second dose is repeated 24 hours later.
Sponsors
University College London (UCL) (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients experiencing an event or procedure which will bring about myocardial injury: 1. Coronary artery bypass surgery +/- valve surgery 2. Primary angioplasty for ST elevation myocardial infarction 3. Thrombolysis for ST elevation myocardial infarction 4. Non-ST elevation myocardial infarction 5. High risk and undergoing percutaneous coronary intervention 6. Aged 18 - 85 years, either sex
Exclusion criteria
Exclusion criteria: 1. Significant co-morbidity 2. Known intolerance to trialled intervention 3. Renal/liver failure 4. In patients undergoing an elective procedure-chest pain within the last 3 days, lack of consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum cTnT and CK-MB (bloods taken before intervention and at 6, 12, 24, 48 and 72 hours post-intervention). | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Inotropic score: calculated using the maximum inotropic dose used on day 1 post-op 2. Ventilation time: assessed from the time of admission into ITU to the time of extubation 3. ITU stay: assessed from the time of admission into ITU to the time of discharge from the unit | — |
Countries
United Kingdom
Outcome results
None listed