Osteopenia, sarcopenia Musculoskeletal Diseases Other disorders of bone density and structure
Conditions
Interventions
Exercise (Ex): 1-year progressive physical training programme that included a supervised circuit training session twice a week and a series of exercises at home 4 days per week. Training was high-impa
the 12-month measurements were performed within a week of ending the treatments. This part of the trial was completed on the 30th August 1997.
A 10-year follow-up measurement was also performed for t
Sponsors
University of Jyvaskyla (Finland)
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. No serious medical conditions 2. No current or previous use of medications including oestrogen, fluoride, calcitonin, biophosphonates or steroids 3. Last menstruation at least 0.5 years but not more than 5 years ago 4. Follicle-stimulating hormone leves greater than 30 iu/litre 5. No contra-indications for exercise and HRT 6. Aged 50 - 57, caucasian post-menopausal women
Exclusion criteria
Exclusion criteria: 1. Serious medical conditions 2. Current or previous use of medications including oestrogen, fluoride, calcitonin, biophosphonates or steroids 3. Currently menstruating or having last menstruation within 0.5 years of the onset of study or longer than 5 years ago 4. Follicle-stimulating hormone leves less than 30 iu/litre 5. Contra-indications for exercise and HRT
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Developing methods for the testing of material and structural changes in the trabecular and cortical bone sites of the lower leg in relation to high-impact exercise and hormone replacement: 1.1. Single photon absorption method 1.2. Computed tomography 1.3. Elastic wave propagation 1.4. Ultrasonography 2. The effects of a high-intensity, explosive-type physical training and hormonal replacement on lower leg muscle mass, structure and performance in post-menopausal women: 2.1. Ultrasonography 2.2. Computed tomography 2.3. Muscle biopsies 2.4. Maximal isometric strength measurements with dynamometer chair 2.5. Measurement of explosive muscle power; ability to elevate the body's centre of gravity during vertical jumps onto a contact mat 2.6. Muscle performance; maximal running speed over 20 m distance All measurements were done at baseline (0 months), at mid-point (6 months) and after completion of the treatments (12 months). | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Examining the molecular mechanism responding to high-intensity, explosive-type physical training and hormonal replacement by using muscle biopsies, taken at baseline, after 0.5 years of study onset and after 1 year of study onset, by microarray and other applicable molecular methods 2. Examining the adaptation of bone collagen metabolism and the different types of muscle fibres to altered force transmission and oestrogen status (using serum and urine samples to determine the content of deoxypyridinoline in overnight (10 hour) samples and using immunohistochemical methods with respective antibodies All measurements were done at baseline (0 months), at mid-point (6 months) and after completion of the treatments (12 months). | — |
Countries
Finland
Outcome results
None listed