Antioxidant efficacy of a cosmetic product Skin and Connective Tissue Diseases
Conditions
Interventions
On each participant, four skin sites on the legs are randomly allocated to receive application of four different treatments daily for 30 days.
Site 1: Test cream, which contains basal cream and 0.1%
Sponsors
Pierre Fabre Dermo Cosmétique
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged 18 years or over 2. Healthy 3. Caucasian skin type: II, III and IV according to Fitzpatrick classification 4. Showing clinical signs of skin ageing due to physiological ageing (chrono-ageing) and chronological ageing 5. Have not been recently involved in any other similar study 6. Agree to not use during all the study period topic products/dietary supplements with similar effect to that one of the product to be tested (antioxidant) 7. Have not had sun exposure on the back area for at least two months prior to the study 8. Free from of sunburn, suntan, scars, or active dermal lesions on the areas of the back selected for the test purposes 9. Test area must be uniform in colour, without nevi, blemishes or solar lentigo and without hairs 10. Agree not to change the daily routine
Exclusion criteria
Exclusion criteria: 1. Pregnant or nursing women 2. History of allergies or sensitivity to cosmetic products, toiletries, sunscreens and/or topical drugs 3. Dermatological problems on the test area 4. Under pharmacological treatment (both locally or systemically) 5. Positive anamnesis for atopy (allergic hypersensitivity affecting parts of the body not in direct contact with the allergen) 6. Use of self-tanning products in the previous month after the date of the study 7. Accustomed to using tanning beds 8. Taking medication with photosensitizing potential, drugs and/or dietary supplements able to induce skin colouring, corticoids, currently or during the month before the study 9. Positive anamnesis for atopy (allergic hypersensitivity affecting parts of the body not in direct contact with the allergen)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Antioxidant activity is measured using Fluorescence Recovery After Photobleaching (FRA) at baseline, 15 and 30 days. | — |
Secondary
| Measure | Time frame |
|---|---|
| Lipid peroxidation is measured by completing a Lipid Peroxidation (MDA) Assay in each area at baseline, 15 and 30 days of cream application. | — |
Countries
Italy
Outcome results
None listed