Topical steroid withdrawal (TSW) Injury, Occupational Diseases, Poisoning
Conditions
Interventions
• Collect information from up to 1000 UK residents who have experienced TSW through an online survey.
• Collect and analyse saliva samples from 50 people who are experiencing TSW, and 50 healthy volun
Sponsors
University of Edinburgh
NHS Lothian
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: For all TSW sections of the study: 1. Self-identify as currently or previously experiencing TSW 2. Aged 18 years or older 3. Resident in the UK 4. Able to give written informed consent For TSW saliva, blood, or skin biopsy donation: 1. Must currently meet NIH TSW criteria, as assessed by the research team using questionnaire data. For healthy volunteer saliva donation: 1. Aged 18 years or older 2. Resident in the UK
Exclusion criteria
Exclusion criteria: For TSW or healthy volunteer saliva, blood, or skin biopsy donation: 1. Pregnancy 2. Uncontrolled medical illness, eg diabetes, ischaemic heart disease, active infection 3. Current use of topical or systemic steroids (i.e. must be currently in steroid withdrawal phase)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Topical steroid withdrawal (TSW) cohort characteristics measured using data collected from an online survey at the time of the survey. These characteristics include historical skin health and topical steroid use, symptoms and timeline of TSW, clinical management of TSW, understanding of TSW and impact of TSW. 2. Salivary cortisol levels will be measured by immunoassay using the saliva samples at one time point. 3. Blood and skin samples will be stored pending approval for use in future planned research. | — |
Secondary
| Measure | Time frame |
|---|---|
| There are no secondary outcome measures | — |
Countries
Scotland, United Kingdom
Contacts
Public ContactSara Brown
Outcome results
None listed