Abdominal aortic aneurysm Circulatory System
Conditions
Interventions
This is an in-silico trial that will make use of routine healthcare data gathered as part of the NHS AAA Screening Programme linked to primary care records for these men. Between 2013 and 2022 approxi
Sponsors
University of Leicester
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: Men invited for AAA screening by the NHS AAA Screening Programme (2013 to date)
Exclusion criteria
Exclusion criteria: Men who have opted out of NHS data sharing or NHS AAA Screening Programme research.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Diagnostic accuracy of AAA screening – sensitivity of targeted screening for AAA detection in comparison to whole population screening. AAA detection will be determined from AAA screening records at a single time point | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Effectiveness of targeted screening – using the baseline of whole population screening the clinical and economic effectiveness of targeted screening will be estimated using a validated discrete event simulation model. Model parameters will be determined from the analysis of AAA screening outcome data at a single time point 2. Diagnostic accuracy will be determined from data provided by the NHS AAA Screening Programme. This consists of attendance for screening and binary screening outcome (attendance yes/no, aneurysm yes/no). The gold standard for diagnostic accuracy will be the observed results from whole population screening. The results of targeted screening will be compared to this with data for AAA screening outcomes for each individual compared across the two strategies at a single time point | — |
Countries
England, United Kingdom
Outcome results
None listed