Topic: Cardiovascular
Conditions
Interventions
Suitable participants awaiting coronary angiography or angioplasty who have impaired kidney function will be stratified into high, medium and low risk groups and then randomly assigned in blocks to re
Sponsors
University College London (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age 18 to 85 2. Male or female gender 3. Awaiting coronary angiography or percutaneous coronary intervention, or (added 09/01/2015) CRTD implantation 4. Renal dysfunction with eGFR (MDRD) <60 ml/min/1.73m2
Exclusion criteria
Exclusion criteria: 1. Age under 18 or over 85 2. Inability to give written informed consent 3. Pregnancy 4. Haemo or peritoneal dialysis patients 5. Contraindication to BP cuff inflation such as significant upper limb peripheral vascular disease 6. Coagulopathy with INR >2.0 7. ST elevation MI/cardiac arrest/cardiogenic shock during admission 8. Participation in another clinical trial within 3 months 9. Intravascular Contrast Exposure within prior 1 month
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Contrast Induced Nephropathy; Timepoint(s): Incidence of creatinine elevation by 25% or 0.5g/dl from baseline at 48 hours. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Cardiovascular endpoints; death, MI, revasc, acute heart failure, haemorrhage, rehospitalisation, haemodialysis at 3 months 2. Neutrophil gelatinase-associated lipocalin (NGAL); Timepoint(s): Serum NGAL elevation from baseline at 6 hours post contrast exposure 3. Persistent CIN; Timepoint(s): Incidence of creatinine elevation by 25% / 0.5g/dl from baseline at 3 months post contrast exposure 4. Proteinuria; Timepoint(s): Elevation of dipstick protein and ACR at 48 hours and 3 months following contrast exposure | — |
Countries
United Kingdom
Outcome results
None listed