Head and neck cancer Cancer
Conditions
Interventions
Tissue samples will be obtained from the Head and Neck Tissue and Data Bank. Immunohistochemistry, expression profiling and miRNA screening to investigate markers of hypoxia will be performed. Copper-
Sponsors
Guy's and St Thomas' NHS Foundation Trust (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients with stage III-IV histologically proven HPV negative oropharyngeal squamous cell carcinoma to be treated with radical concomitant chemotherapy and radiotherapy 2. Patients have consented to their original biospy being stored in the tissue bank at GSTFT 3. Age > 18 years 4. ECOG Performance Status 12 weeks 6. Adequate organ function and absence of other major concomitant illness, allowing the patient to tolerate the delivery of the radiotracer 7. Patients must be able to provide written and voluntary informed consent 8. All women of childbearing age must have a negative serum or urine pregnancy test documented within 72 hours prior to study enrollment 9. Male and female participants
Exclusion criteria
Exclusion criteria: 1. Patients with impaired renal function (serum creatinine > 200) 2. Patients with severely impaired liver function 3. Serious intercurrent conditions or other nonmalignant illnesses that are uncontrolled or whose control may be affected by participation in this study 4. Any patient who has urinary or faecal incontinence 5. Previous history of cancer other than skin basal cell carcinoma 6. ECOG Performance Status >/= 3 7. Pregnant or breastfeeding women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Characterisation and correlation of molecular and imaging biomarkers of hypoxia | — |
Secondary
| Measure | Time frame |
|---|---|
| No secondary outcome measures | — |
Countries
United Kingdom
Outcome results
None listed