Skip to content

One hundred percent oxygen versus titrated oxygen following the return of a heartbeat after out of hospital cardiac arrest: a feasibility study

Cluster randomised comparison of the effectiveness of 100% oxygen versus titrated oxygen in patients with a sustained return of spontaneous circulation following out of hospital cardiac arrest: a feasibility study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN49548506
Enrollment
81
Registered
2016-11-24
Start date
2015-01-13
Completion date
Unknown
Last updated
2019-02-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Specialty: Injuries and emergencies, Primary sub-specialty: Injuries and emergencies Circulatory System Out of hospital cardiac arrest (OHCA)

Interventions

Paramedics employed full-time by South Western Ambulance Service NHS Foundation Trust (SWAST) on front-line operational duties, and who are based in Bristol or Bath, will be invited to participate in

Sponsors

University Hospitals Bristol NHS Foundation Trust
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Sustained a cardiac arrest in the pre-hospital setting believed to be of a non-traumatic cause. Cardiac arrest will be defined according to the Utstein Definition as "the cessation of cardiac mechanical activity as confirmed by the absence of signs of circulation. If an EMS provider or physician did not witness the cardiac arrest, he/she may be uncertain as to whether a cardiac arrest actually occurred." For the purposes of this study, patients will be eligible for inclusion if they are attended by ambulance staff and are believed by those staff to have suffered a cardiac arrest. 2. ROSC (indicated by signs of circulation: usually a palpable central or peripheral pulse) for greater than 2 minutes (sustained ROSC) has been achieved 3. Attended by a paramedic participating in the trial 4. Known, or believed to be, 18 years of age, or older

Exclusion criteria

Exclusion criteria: 1. Less than 18 years old 2. Cardiac arrest believed to have been caused by trauma (including hanging and drowning) 3. Entered into the study previously 4. Detained by Her Majesty's Prison Service

Design outcomes

Primary

MeasureTime frame
Recruitment rate is measured as the proportion of eligible paramedics attending training and consenting to take part at the end of the recruitment period.

Secondary

MeasureTime frame
1. Proportion of surviving participants providing quality of life data at discharge and 90 days is measured by the number of patients completing the modified Rankin Scale, EuroQol EQ-5D-5L and the SF-36 instruments at discharge and 90 days following OHCA 2. Survival to discharge and 90-days is measured by reviewing patient notes at hospital discharge and 90 days following OHCA

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026