Non-invasive, bedside assessment of systemic endothelial function: a predictor of mortality in intensive care?

Function of the Endothelium in Critical Care: a prospective observational cohort study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN49531007

Enrollment

182

Registered

2009-06-05

Start date

2007-07-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Systemic endothelial function in critical care Haematological Disorders Systemic endothelial function

Interventions

Recruited patients will be categorised as follows: 1. Medical 2. Surgical 3. Trauma 4. Burns Baseline information to be recorded will include: 1. Patient demographics 2. Physiological data 3. Plas

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: All adult patients admitted to the regional intensive care unit at the Royal Group of Hospitals, Belfast will be eligible for inclusion in the study.

Exclusion criteria

Exclusion criteria: 1. Aged less than 18 years old 2. Pregnancy 3. Inability to achieve radial arterial access 4. Known allergy or sensitivity to salbutamol or glyceryl trinitrate (GTN) 5. Patients transferred from other intensive care units 6. Patients unlikely to survive more than 24 hours 7. Patients with an advance directive regarding limitation of treatment 8. Patients who have a "Do Not Attempt Resuscitation" (DNAR) order in place 9. Lack of consent

Design outcomes

Primary

Measure	Time frame
Intensive Care Unit (ICU) mortality	—

Secondary

Measure	Time frame
1. Length of ICU stay 2. Number of ventilator days 3. Incidence of organ failures 4. Need for continuous renal replacement therapy 5. Duration of inotropic support	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026