Outcomes of intraoperative haemofiltration for patients with impaired kidney function undergoing coronary artery bypass graft surgery

The impact of continuous haemofiltration with high volume fluid exchange during cardiopulmonary bypass surgery on the recovery of patients with impaired renal function - a pilot study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN49513454

Enrollment

Registered

2010-07-06

Start date

2010-07-01

Completion date

Unknown

Last updated

2016-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Preoperative renal impairment

Interventions

Patients that fulfil inclusion and exclusion criteria will be fully informed about the study and asked to give consent for the study. They will be randomised into two study groups by a computer-genera

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Consenting men and women must be at least 18 years old 2. High-risk patients elective for on-pump coronary artery bypass graft surgery (CABG) 3. Impaired renal function established preoperatively by an estimated glomerular filtration rate (eGFR) <60 ml/min measured within 4 weeks before surgery

Exclusion criteria

Exclusion criteria: 1. Patients undergoing surgery on the great vessels (aortic surgery) 2. Patients with significantly impaired liver function (serum bilirubin> 60 or INR>2 without anticoagulation) 3. Patients who are further down the line of renal failure or on-dialysis 4. Patients with malignancy 5. Those that are pregnant

Design outcomes

Primary

Measure	Time frame
Incidents of ICU stay >3 days for patients with renal impairment identified as an estimated glomerular filtration (eGFR) <60 ml/min	—

Secondary

Measure	Time frame
1. Clinical outcomes: 1.1. Composite of perioperative incidences: 1.1.1. Bleeding 1.1.2. Sepsis 1.1.3. Death 1.1.4. Arrhythmias 1.1.5. Stroke 1.1.6. Myocardial infarction 1.2. Need for postoperative continuous veno-venous haemofiltration (CVVH) in the ICU and wards - Indications for requirement of postoperative continuous veno-venous haemofiltration must adhere to our strict NHS Trust criteria and guidelines. 1.3. Mechanical ventilation time 1.4. Hospital stay 1.5. eGFR at 6 weeks follow-up 2. Economic outcomes: Resource utilisation and costs associated with each of the two pilot arms such as: 2.1. ICU stay and hospital stay 2.2. Mechanical ventilation 2.3. Medications 2.4. Tests and procedures undertaken until the end of the follow-up period	—

Measure

Time frame

1. Clinical outcomes: 1.1. Composite of perioperative incidences: 1.1.1. Bleeding 1.1.2. Sepsis 1.1.3. Death 1.1.4. Arrhythmias 1.1.5. Stroke 1.1.6. Myocardial infarction 1.2. Need for postoperative continuous veno-venous haemofiltration (CVVH) in the ICU and wards - Indications for requirement of postoperative continuous veno-venous haemofiltration must adhere to our strict NHS Trust criteria and guidelines. 1.3. Mechanical ventilation time 1.4. Hospital stay 1.5. eGFR at 6 weeks follow-up 2. Economic outcomes: Resource utilisation and costs associated with each of the two pilot arms such as: 2.1. ICU stay and hospital stay 2.2. Mechanical ventilation 2.3. Medications 2.4. Tests and procedures undertaken until the end of the follow-up period

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Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 22, 2026