Advanced puberty Nutritional, Metabolic, Endocrine Precocious puberty
Conditions
Interventions
The patients were sampled after being admitted to the hospital,every 45 minutes for 3 hours and then 4, 6, 8, 10 and 12 hours after metformin intake, 850 mg/d.
The girls were started on metformin at
Sponsors
Hospital Sant Joan de Déu, University of Barcelona (Spain)
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: The study population consisted of 6 non-obese, Caucasian girls receiving metformin (850 mg/d at dinner time) after a history of low-birthweight (Z-score ¡Ü -1.5 for gestational age) and early-normal puberty (onset of Tanner breast stage 2 at age 8 yr; increase of uterine and ovarian size by ultrasound; pubertal gonadotropin response to GnRH agonist).
Exclusion criteria
Exclusion criteria: 1. A family or personal history of diabetes mellitus 2. A history of precocious pubarche or the presence of other signs of androgen excess 3. Evidence for thyroid dysfunction or glucose intolerance 4. Intake of medications known to affect gonadal function or carbohydrate metabolism.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Height velocity: according to local reference curves: Ferrández-Longás A, Mayayo E, Labarta JI, Bagué L, Puga B, Rueda C, Ruiz-Echarri M, Labena C. Estudio longitudinal de crecimiento y desarrollo. Centro Andrea Prader. Zaragoza 1980-2002. In ERGON, ed. Patrones de crecimiento y desarrollo en España. Atlas de gráficas y tablas., pp 61-115. Madrid: 2004 2. Pubertal status: according to Tanner standards (Marshall WA, Tanner JM. Variations in the pattern of pubertal changes in girls. Arch Dis Child 1969; 44:291-303) | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Bone age: according to Greulich & Pyle 2. Uterine and ovarian size: as measured by ultrasound and according to: Griffin IJ, Cole TJ, Duncan KA, Hollman AS, Donaldson MDC. Pelvic ultrasound measurements in normal girls. Acta Paediatr 1995; 84:536-543 | — |
Countries
Spain
Outcome results
None listed