Study on gum healing in smokers using hyaluronic acid during surgery

Effect of local application of hyaluronic acid on wound healing after crown lengthening procedure in smokers: a double-blind randomized controlled clinical trial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN49281528

Enrollment

Registered

2025-08-04

Start date

2021-01-01

Completion date

Unknown

Last updated

2025-09-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post-surgical wound healing in smokers following periodontal crown lengthening Oral Health

Interventions

Patients were randomly assigned in a 1:1 ratio to one of two groups using a computer-generated randomisation list. In the test group, cross-linked hyaluronic acid gel (hyaDENT BG, Bioscience, Germany)

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Male or female 2. Aged between 18 and 60 years 3. Individuals in good general health with no systemic conditions affecting wound healing 4. Current smokers consuming 10 or more cigarettes per day 5. Referred for crown lengthening surgery 6. Able to understand the study and provide written informed consent 7. Willing and able to attend all scheduled follow-up visits at 2 and 6 weeks post-surgery

Exclusion criteria

Exclusion criteria: 1. Individuals diagnosed with systemic conditions known to impair wound healing (e.g., uncontrolled diabetes, osteoporosis) 2. Pregnant or breastfeeding individuals 3. Recent use of systemic antibiotics or anti-inflammatory drugs within the past 2 months 4. Current use of medications that may alter periodontal healing, such as corticosteroids, immunosuppressants, or bisphosphonates 5. Presence of dental restorations that obstruct accurate probing depth measurements at the surgical site 6. Evidence of untreated active periodontal infection 7. Inability or not willing to provide written informed consent

Design outcomes

Primary

Measure	Time frame
Wound healing measured using the Landry healing index at 2 weeks and 6 weeks post-surgery	—

Secondary

Measure	Time frame
1. Pain measured using a visual analogue scale (VAS) at 2 weeks and 6 weeks post-surgery 2. Probing pocket depth (PPD) measured using a UNC-15 periodontal probe at baseline, 2 weeks, and 6 weeks post-surgery 3. Plaque Index (PI) measured using the Silness and Loe index at baseline, 2 weeks, and 6 weeks post-surgery 4. Gingival Index (GI) measured using the Loe and Silness index at baseline, 2 weeks, and 6 weeks post-surgery 5. Bleeding on probing (BOP) measured using dichotomous bleeding scores at baseline, 2 weeks, and 6 weeks post-surgery 6. Radiographic bone height measured using standardized vertical bitewing radiographs at baseline and 6 weeks post-surgery	—

Measure

Time frame

1. Pain measured using a visual analogue scale (VAS) at 2 weeks and 6 weeks post-surgery 2. Probing pocket depth (PPD) measured using a UNC-15 periodontal probe at baseline, 2 weeks, and 6 weeks post-surgery 3. Plaque Index (PI) measured using the Silness and Loe index at baseline, 2 weeks, and 6 weeks post-surgery 4. Gingival Index (GI) measured using the Loe and Silness index at baseline, 2 weeks, and 6 weeks post-surgery 5. Bleeding on probing (BOP) measured using dichotomous bleeding scores at baseline, 2 weeks, and 6 weeks post-surgery 6. Radiographic bone height measured using standardized vertical bitewing radiographs at baseline and 6 weeks post-surgery

—

Countries

Saudi Arabia

Contacts

Public ContactDalal AlOtaibi

dalalotaibi@ksu.edu.sa+966 (0)50 537 4266

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026