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Understanding viral infection and respiratory symptoms following admission to hospital

Understanding Infection, Viral Exacerbation and Respiratory Symptoms at Admission - Longitudinal (UNIVERSAL) study

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ISRCTN
Registry ID
ISRCTN49183956
Enrollment
2000
Registered
2022-08-09
Start date
2022-06-17
Completion date
Unknown
Last updated
2026-02-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Respiratory viral infections Infections and Infestations

Interventions

This is an observational cohort study to develop a prospective longitudinal clinical database. All adults admitted with respiratory syndromes to participating hospital sites will be asked to participa

Sponsors

University Hospital Southampton NHS Foundation Trust
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 100 Years

Inclusion criteria

Inclusion criteria: Current inclusion criteria as of 09/09/2022: Stage 1 1. Aged =18 years 2. Has symptoms of an acute respiratory illness (ARI) 3. Is a respiratory inpatient Plus, for Stage 2 3. Has positive test result for respiratory viral infection _____ Previous inclusion criteria: Stage 1 1. Aged =18 years old 2. Has symptoms of an acute respiratory illness (ARI)* Plus, for Stage 2 3. Has positive test result for respiratory viral infection

Exclusion criteria

Exclusion criteria: 1. Combined nasal and throat swabbing cannot be performed (patient decision or contraindication to procedure) 2. Consent declined or consultee consent declined 3. Previously recruited into this study

Design outcomes

Primary

MeasureTime frame
1. The incidence rate of different respiratory viruses in admitted, samples patient population measured using descriptive statistics during the winter season (a 1-year period) across UK sites 2. Clinical and biological predictors of progression of disease, recovery and length of stay in admitted, samples patient population measured using multiple logistic regression analysis with backward selection during the winter season (a 1-year period) across UK sites

Secondary

MeasureTime frame
1. Time to recovery for different viruses and patient factors measured using univariate analyses at baseline/recovery 2. Cost estimate per patient based on Healthcare Resource Group (HRG) coding at baseline/discharge

Countries

England, Scotland, United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 19, 2026