Augmented renal clearance (ARC) in critically ill patients Other
Conditions
Interventions
Eligible adult ICU patients (=18 years) will undergo serial 24-hour urine collections on days 1, 3, 5, and 7 of ICU admission. In non-catheterized patients: Urine collection begins after the bladder
Sponsors
National Institute of Traumatology & Orthopaedic Rehabilitation
Eligibility
Sex/Gender
All
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1. Adults aged =18 years 2. ICU stay =24 hours 3. Informed consent obtained from patient or legal representative
Exclusion criteria
Exclusion criteria: 1. Chronic kidney disease (CKD stage =3 or baseline eGFR <60 mL/min) 2. Receiving renal replacement therapy 3. Kidney transplant recipients 4. Pregnant or lactating women 5. Incomplete urine collection or missing laboratory data 6. Hemodynamic instability precluding safe sampling
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Prevalence of ARC (=120 mL/min/1.73 m²) as measured by 24-hour urinary creatinine clearance within first 7 days of ICU admission | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Risk factors associated with ARC (demographic, physiological, and clinical parameters) within the first 7 days of ICU admission 2. Comparison between measured and estimated CrCl (using Cockcroft–Gault formula) within the first 7 days of ICU admission 3. Clinical outcomes (ICU length of stay, mortality, treatment response) up to 28 days or until ICU discharge/death | — |
Countries
Bangladesh
Contacts
Public ContactSyed Tariq;Syeda Nusrat Reza;Jahan
;
Outcome results
None listed