Chronic cervicofacial lymphadenitis Circulatory System Lymphadenitis
Conditions
Interventions
To compare surgical excision of involved lymph nodes with antibiotic therapy consisting of a three-month course of Clarithromycin and Rifabutin.
Sponsors
The Netherlands Organisation for Health Research and Development (ZonMw) (The Netherlands)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Children between 0 - 15 years old with a possible NTM lymphadenitis were referred by pediatricians, otolaryngologists, oral and maxillofacial surgeons and general practitioners from all over the country. Inclusion criteria: an enlarged cervicofacial lymphadenitis for a period longer than three weeks, with negative serology for other infectious causes of chronic lymphadenitis (Cytomegalo Virus [CMV], Epstein-Barr Virus [EBV], adenovirus, bartonella and toxoplasmosis).
Exclusion criteria
Exclusion criteria: Excluded were immunocompromised patients and patients using immunosuppressive drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary endpoint was cure, defined as regression of the enlarged lymph node by at least 75%, with cure of the fistula and total skin closure without local recurrence or de novo lesions at six months, as assessed by clinical and ultrasound evaluation. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcome measures were surgical complications and side effects of the medication. | — |
Countries
Netherlands
Outcome results
None listed