Addiction Mental and Behavioural Disorders Mental and behavioural disorders due to use of opioids
Conditions
Interventions
The abstinent heroin addicts were randomly assigned to three treatment groups:
1. Placebo
2. 5 µg tetrodotoxin
3. 10 µg tetrodotoxin
Eac
Sponsors
The National Basic Research Program of China (973 Program) (China)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Men or non-pregnant/nursing women 18 - 45 years old 2. Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM- IV) criteria for heroin dependence, but opiate-free for at least one month 3. No use of cocaine and other drugs
Exclusion criteria
Exclusion criteria: 1. Current or past cardiovascular disease 2. History of allergy (food, medicine) 3. Current or past psychiatric illness 4. Neurological signs and/or history of neurological disease 5. Current medical illness 6. Participation in other clinical trials of medications within the past three month
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cue-induced craving and anxiety. Both the primary and secondary outcomes were measured at 0 minutes (baseline, before TTX administration), 60 minutes (1 hour after TTX administration), 65 minutes (immediately after the first video presentation), 75 minutes (before the second video presentation), and 80 minutes (immediately after the second video presentation). | — |
Secondary
| Measure | Time frame |
|---|---|
| Heart rate and blood pressure. Both the primary and secondary outcomes were measured at 0 minutes (baseline, before TTX administration), 60 minutes (1 hour after TTX administration), 65 minutes (immediately after the first video presentation), 75 minutes (before the second video presentation), and 80 minutes (immediately after the second video presentation). | — |
Countries
China
Outcome results
None listed