Intracranial angioplasty Surgery Ischemic stroke attributed to an intracranial stenosis
Conditions
Interventions
Stent-assisted angioplasty of the offending intracranial stenosis
Sponsors
The Ministry of Health of the People's Republic of China
Eligibility
Inclusion criteria
Inclusion criteria: 1. 18-75 years of age 2. Recurrent ischemic events (transient ischemic attack and/or stroke) attributed to an intracranial stenosis = 50% at digital subtraction angiography (DSA) 3. Performed intracranial angioplasty and stent placement
Exclusion criteria
Exclusion criteria: 1. Intracranial hemorrhage and major ischemic stroke (NIHSS =8) in the same hemisphere as the target lesion within 6 weeks 2. Concurrent severe extracranial artery stenosis and angioplasty and stent placement needed to be performed 3. Concurrent intracranial tumors, cerebral AVM and aneurysms 4. History of heparin allergy 5. Received perioperative heparin or surgical procedures requiring systemic heparinization 6. Preoperative platelet or coagulation abnormalities 7. Patients were not eligible if they could not cooperate with the study procedures or provide informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Efficacy end point was thromboembolus complications within 24h. 2. Safety end point was intracranial bleeding complications within 24h. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Intraoperative activated clotting time monitoring 2. Puncture site complications | — |
Countries
China
Outcome results
None listed