Patients after surgical removal of impacted mandibular third molar Oral Health
Conditions
Interventions
In this split-mouth randomized single-center clinical trial, patients (n = 20, aged 18-25 years) following surgical removal of two impacted mandibular third molar (1 month apart) will be asked to take
Sponsors
Chiang Mai University
Eligibility
Sex/Gender
All
Age
18 Years to 25 Years
Inclusion criteria
Inclusion criteria: 1. Healthy according to the American Society of Anesthesiologists (ASA) criteria: Level I and II 2. Male and female 3. 18-25 years old 4. Had left and right lower mandibular third molars impacted
Exclusion criteria
Exclusion criteria: 1. History of ibuprofen sensitivity 2. Painful of mandibular third molar or maxillofacial area before operation 3. Taken an analgesic drug for one week before surgical removal of impacted mandibular third molar 4. Psychiatric 5. Non-compliance on recording pain and symptoms after operation 6. Unable to revisit for the next follow-up
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The following primary outcome measures were assessed in saliva specimens collected before tooth extraction and on days 3 and 7 after tooth extraction: 1. Alpha-amylase activity measured using a colorimetric method 2. MMP9 concentrations measured using sandwich-type ELISA kits 3. TGF-1 concentrations measured using sandwich-type ELISA kits | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain was measured using a visual analogue scale (VAS) every day for 7 days | — |
Countries
Thailand
Contacts
Public ContactVuttinun;Vuttinun Chatupos;Chatupos
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Outcome results
None listed