Heroin addiction Mental and Behavioural Disorders Mental and behavioural disorders due to use of opioids
Conditions
Interventions
There are three groups:
1. Propranolol 40 mg
2. Cortisol 50 mg
3. Placebo
The trial is an acute administration drug and all of them wer
Sponsors
The National Basic Research Program of China (973 Program) (China)
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: 1. Aged from 20 to 40 years, male only 2. Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV) criteria for heroin dependence with opiate free for at least one month 3. No use of other drugs
Exclusion criteria
Exclusion criteria: 1. Current use of any medications 2. Current DSM-IV diagnosis of any affective, anxiety, or psychotic disorder 3. Current dependence on any substance besides heroin and nicotine (based on DSM-IV criteria) 4. Risk factors for untoward side effects from propranolol and cortisol (i.e., irregular heartbeats, history of cardiogenic shock, history of severe heart failure, asthma, fungal infections, hyperlipidaemia, history of hypertension, or abnormal electrocardiogram [ECG] or other laboratory findings)
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| The effect of propranolol and cortisol on salivary cortisol levels 1 hour after drug administration. | — |
Primary
| Measure | Time frame |
|---|---|
| The effect of propranolol and cortisol administration on heroin-related memory retrieval in abstinent heroin addicts, measured 1 hour after the medicine treatment. | — |
Countries
China
Outcome results
None listed