Acute Coronary Syndromes Circulatory System
Conditions
Interventions
An additional blood sample will be taken at the same time as routine sampling for the majority of patients. Some patients may require blood to be drawn after they have had routine blood samples. To mi
Sponsors
Manchester University NHS Foundation Trust
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged 18 years or more 2. Presenting to the emergency department with a primary complaint of pain or discomfort in the chest, epigastrium, arm(s), jaw, neck or throat, which the treating clinician suspects may have been caused by an acute coronary syndrome
Exclusion criteria
Exclusion criteria: 1. Overt ST-elevation myocardial infarction (STEMI) requiring immediate referral for coronary revascularization 2. Another reason requiring hospital admission, even if the diagnosis of acute coronary syndrome is excluded (e.g. arrhythmia, gastrointestinal bleeding, sepsis) 3. No symptoms in the previous 12 hours 4. No capacity, or unwillingness, to provide written informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Diagnostic accuracy of the Siemens Atellica VTLi high-sensitivity cardiac troponin I assay, measured on arrival in the emergency department and 1 hour later using thresholds below the 99th percentile upper reference limit, for the target condition of acute myocardial infarction | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Incidence of major adverse cardiac events (MACE, cardiovascular death or AMI occurring within 30 days of enrolment), as measured by a review of medical records and/or GP questionnaire at 30 days 2. Incidence of coronary revascularization, as measured by review of medical records and/or GP questionnaire at 30 days 3. All-cause mortality, as measured by review of medical records and/or GP questionnaire at 30 days 4. Length of hospital stay, as measured by review of medical records and/or GP questionnaire at 30 days | — |
Countries
England, United Kingdom
Contacts
Public ContactRichard Body
Outcome results
None listed