The role of glutamate in the development of phantom limb pain

A randomised double blind trial of the effect of pre-emptive epidural ketamine on persistent pain after lower limb amputation

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN48374927

Enrollment

Registered

2001-03-01

Start date

2001-01-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain Signs and Symptoms Pain

Interventions

All patients will have spinal and epidural anaesthesia with bupivacaine established before amputation and will receive an epidural infusion of bupivacaine for 48 to 72 hours after surgery for post-ope

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients undergoing lower limb amputation for peripheral vascular disease or as a result of complications of diabetes mellitus 2. Able to give informed consent and cooperate with pain assessment

Exclusion criteria

Exclusion criteria: Not provided at time of registration

Design outcomes

Primary

Measure	Time frame
Incidence and severity of post-amputation pain measured at one year.	—

Secondary

Measure	Time frame
Not provided at time of registration	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026