Hormonal and metabolic effects of diet and exercise programs in obese women with polycystic ovary syndrome (Hormonella och metabola effekter av diet- och motionsprogram hos överviktiga kvinnor med polycystiskt ovariesyndrom)

Hormonal and metabolic effects of diet and exercise programs in obese women with polycystic ovary syndrome : a prospective randomised controlled trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN48342048

Enrollment

Registered

2011-06-01

Start date

2003-01-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Polycystic ovary syndrome (PCOS) Nutritional, Metabolic, Endocrine Polycystic ovarian syndrome

Interventions

The interventions lasted for four months, with monthly visits and follow-up was continued for more than one year after termination of the programs. The diets were designed individually under the clos

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Women aged 18-40 years diagnosed with PCOS and having body mass index (BMI) > 27

Exclusion criteria

Exclusion criteria: 1. The presence of other disease or a different endocrine disorder 2. An eating disorder 3. Smoking 4. Continuous medication including insulin sensitising drugs

Design outcomes

Primary

Measure	Time frame
Immediately before this study, after four months of intervention and at the time of the long-term follow-up, each patient underwent a general health control involving determination of blood pressure, weight, height and waist/hip ratio (WHR). 1. All gynecological examinations including transvaginal ultrasound using Sonoline SI-250 equipment (Siemens Healthcare Diagnostics, Deerfield, IL, USA) were performed by the same investigator. The ovarian parameters evaluated were the maximal number of follicles in one plane and the volumes of the largest follicle and of the entire ovary. Menstrual bleedings were recorded and ovulation confirmed on the basis of an elevation in the serum level of progesterone during the luteal phase of the menstrual cycle. 2. For determination of body composition, the patients were examined by dual energy X-ray absorptiometry (DXA) employing a Lunar Prodigy Advance whole body scanner (GE medical systems, Fairfield, CT, USA).	—

Measure

Time frame

Immediately before this study, after four months of intervention and at the time of the long-term follow-up, each patient underwent a general health control involving determination of blood pressure, weight, height and waist/hip ratio (WHR). 1. All gynecological examinations including transvaginal ultrasound using Sonoline SI-250 equipment (Siemens Healthcare Diagnostics, Deerfield, IL, USA) were performed by the same investigator. The ovarian parameters evaluated were the maximal number of follicles in one plane and the volumes of the largest follicle and of the entire ovary. Menstrual bleedings were recorded and ovulation confirmed on the basis of an elevation in the serum level of progesterone during the luteal phase of the menstrual cycle. 2. For determination of body composition, the patients were examined by dual energy X-ray absorptiometry (DXA) employing a Lunar Prodigy Advance whole body scanner (GE medical systems, Fairfield, CT, USA).

—

Secondary

Measure	Time frame
Improved insulin sensitivity - In a resting and fasting state at 8:00 am a blood sample was collected from a peripheral vein and the serum separated by centrifugation and stored at ? 70 degree celsius, pending analysis for hormones, binding proteins and glucose. Evaluated immediately before this study, after four months of intervention and at the time of the long-term follow-up	—

Countries

Sweden

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 23, 2026