Analysis of water and electrolyte balance during osmotherapy in meningitis/encephalitis

Assessment of one dose Mannitol influence on hydration and electrolytes concentration in patients with viral meningitis

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN48274252

Enrollment

100

Registered

2017-04-04

Start date

2016-08-01

Completion date

Unknown

Last updated

2022-03-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Tick-borne encephalitis/meningitis Infections and Infestations Tick-borne encephalitis/meningitis

Interventions

All patients with meningitis/encephalitis receive Mannitol as a standard treatment. However, participants in this trial are monitored more closely for potential water and electrolytes balance in order

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Adults aged 18 years old and older 2. Hospitalised due to tick-borne encephalitis in the Department of Infectious Diseases and Neuroinfections Medical University in Bialystok 3. Tick-borne encephalitis diagnosed based on clinical picture, cerebrospinal fluid (CSF) examination and specific antibodies presence in serum and TBE antibodies titer measured with Enzygnost Anti-TBE/FSME Virus (IgG, IgM) Siemens test

Exclusion criteria

Exclusion criteria: Lack of agreement to study terms

Design outcomes

Primary

Measure	Time frame
1. Hydration status is measured using whole body bioelectrical impedance with multiple frequency equipment BodyStat QuadScan 4000 at baseline and one hour 2. Electrolyte concentration in blood is analyzed in the hospital laboratory in accordance with standardized methodology at baseline and one hour	—

Secondary

Measure	Time frame
1. Total Body Water volume (TBW) is measured using whole body bioelectrical impedance with multiple frequency equipment BodyStat QuadScan 4000 at baseline and one hour 2. Internal body water volume is measured using whole body bioelectrical impedance with multiple frequency equipment BodyStat QuadScan 4000 at baseline and one hour 3. External Body water volume is measured using whole body bioelectrical impedance with multiple frequency equipment BodyStat QuadScan 4000 at baseline and one hour 4. Third space body water and electrolytes concentration is measures using whole body bioelectrical impedance with multiple frequency equipment BodyStat QuadScan 4000 at baseline and one hour	—

Measure

Time frame

1. Total Body Water volume (TBW) is measured using whole body bioelectrical impedance with multiple frequency equipment BodyStat QuadScan 4000 at baseline and one hour 2. Internal body water volume is measured using whole body bioelectrical impedance with multiple frequency equipment BodyStat QuadScan 4000 at baseline and one hour 3. External Body water volume is measured using whole body bioelectrical impedance with multiple frequency equipment BodyStat QuadScan 4000 at baseline and one hour 4. Third space body water and electrolytes concentration is measures using whole body bioelectrical impedance with multiple frequency equipment BodyStat QuadScan 4000 at baseline and one hour

—

Countries

Poland

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026