Is it more beneficial for appetite and weight management to exercise once or twice a day?

The effect of exercising once vs. twice a day on gastrointestinal function, metabolic responses and appetite in healthy males: a randomised cross over trial.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN48264634

Enrollment

Registered

2018-12-11

Start date

2018-12-17

Completion date

Unknown

Last updated

2021-03-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obesity Nutritional, Metabolic, Endocrine Obesity

Interventions

Participants will complete two 7h experimental trials in a randomised cross-over design, where each participant will complete both trial arms

exercise once and twice a day separated by a minimum of 7 days. One trial will consist of a one off 60-min cycle at 70% peak maximal oxygen uptake. After completion of this single bout of exercise, pa

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria: 1. Healthy males 2. Age between 18-40 years 3. Body mass index = <29.9 kg/m2 4. Non-smokers 5. No history of GI symptoms 6. Not consuming prescription medication, or no other relevant medical conditions assessed by a medical screening questionnaire. 7. Subsequently be physically active, in order to complete the trials.

Exclusion criteria

Exclusion criteria: 1. Lactose Intolerant 2. Vegan

Design outcomes

Primary

Measure	Time frame
1. Gastric emptying rate of a semi-solid meal will be measured using the 13C breath test . Breath samples will be collected at baseline and every 15min for a two-hour period. 2. Circulating levels of key gut hormones and metabolic markers. Blood samples will be collected at baseline, pre-milkshake, 1h-post milkshake, 2h-post milkshake, pre-semi-solid meal ingestion, 1-h post meal ingestion and 2h post meal ingestion 3. Substrate oxidation will be measured using a breath-by breath gas analyser at rest, during exercise sessions and every 30 min post food ingestion for 2h 4. Visual analogue scales will be used to measure subjective sensations of appetite at rest, pre-meal ingestion and every 30min post food ingestion for 2h. 5. 24h post trial energy intake using weighed food intake dietary record	—

Measure

Time frame

1. Gastric emptying rate of a semi-solid meal will be measured using the 13C breath test . Breath samples will be collected at baseline and every 15min for a two-hour period. 2. Circulating levels of key gut hormones and metabolic markers. Blood samples will be collected at baseline, pre-milkshake, 1h-post milkshake, 2h-post milkshake, pre-semi-solid meal ingestion, 1-h post meal ingestion and 2h post meal ingestion 3. Substrate oxidation will be measured using a breath-by breath gas analyser at rest, during exercise sessions and every 30 min post food ingestion for 2h 4. Visual analogue scales will be used to measure subjective sensations of appetite at rest, pre-meal ingestion and every 30min post food ingestion for 2h. 5. 24h post trial energy intake using weighed food intake dietary record

—

Secondary

Measure	Time frame
1. Ratings of perceived exertion using the Borg scale and heart rate will be recorded pre exercise and every 15min during exercise	—

Countries

United Kingdom

Contacts

Public ContactLewis Mattin

lewis.mattin@stu.mmu.ac.uk+44 (0)1612471215

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026