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Can new dental fillings induce regeneration of damaged teeth?

Experimental pulp capping with hydraulic calcium silicate cements induces a range of responses including regeneration of tubular dentine

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN48235766
Enrollment
16
Registered
2022-05-19
Start date
2017-08-01
Completion date
Unknown
Last updated
2022-08-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Treatment of disease of the dental pulp Oral Health

Interventions

Direct pulp capping procedure using MTA or Biodentine. MTA is the control/gold standard. After 6 months the teeth were extracted and histologically evaluated. Random sequence generation was performed

Sponsors

Dublin Dental University Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Male or female patients aged between 14-50 years (patients under 18 years required the consent of a parent/guardian) with an experimental tooth responding positively to pulp sensibility testing (cold thermal and electric), which was scheduled for extraction. The tooth was to be extracted for either orthodontic or prevention reasons and needed to be completely caries-free.

Exclusion criteria

Exclusion criteria: Teeth excluded from participation in the trial were: non-vital or carious teeth, teeth that could not be isolated with a rubber dam or teeth that required sectioning of the roots in order to be extracted.

Design outcomes

Primary

MeasureTime frame
Dental hard tissue bridge formation: Histology at 6 months

Secondary

MeasureTime frame
Discoloration: Photographed at 6 months

Countries

Ireland

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026