Osteoarthritis, NSAID-induced gastropathy Musculoskeletal Diseases Osteoarthritis
Conditions
Interventions
The patients were randomised in two groups, using methods of envelopes, to:
1. Group ZG (n = 21): ginger and glucosamine combination (Zinaxin Glucosamine: 170 mg ginger extract [Zingiber officinalis,
Sponsors
Central Scientific Research Institute of Gastroenterology (Russia)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged over 18 years, either sex 2. Osteoarthritis (OA) pain syndrome availability of more than 40 mm according to Visual Analogue Scale (VAS) 3. Requiring anti-inflammatory therapy assignment 4. NSAID-gastropathy or dyspepsia development from NSAID therapy in anamnesis 5. Informed patient consent to administer the preparation 6. Compliance with the listed research protocol
Exclusion criteria
Exclusion criteria: 1. Ulcer presence during upper gastrointestinal (GI) endoscopy and more than 5 stomach mucosa and/or duodenum erosions, and/or erosive oesophagitis 2. High risk of cardiological complications, arterial hypertension, cardiac insufficiency greater than II degree, myocardial infarction or apoplectic attack in anamnesis during the previous 3 years, chronic kidney disease, liver insufficiency, bronchial asthma, subcompensated or decompensated diabetes mellitus, oncological diseases 3. NSAID administration, aspirin in anti-aggregant doses, glucocorticosteroids 4. Pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Upper GI lesions (erosion, ulcer) were assessed on the 28 day of treatment with upper GI endoscopy | — |
Secondary
| Measure | Time frame |
|---|---|
| Gastritis | — |
Countries
Russian Federation
Outcome results
None listed