Transfusion induced complications = transfusion associated complications? study

The effects of leukocyte filtered versus buffy coat depleted erythocyte transfusions in major surgery patients

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN48093674

Enrollment

1548

Registered

2005-12-20

Start date

2000-03-23

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Blood transfusions complications Signs and Symptoms Blood transfusions

Interventions

Transfusions of filtered red blood cell concentrates versus transfusion of stored buffy coat depleted red blood cell concentrates.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Acute aneurysm-, elective aneurysm-, orthopaedic- and large gastro-intestinal surgery patients.

Exclusion criteria

Exclusion criteria: 1. Under 18 years of age 2. Transfusions received within 3 months prior to inclusion 3. Pre existing medical indication for filtered red blood cell transfusions

Design outcomes

Primary

Measure	Time frame
Postoperative: 1. In-hospital mortality 2. Duration of intensive care stay	—

Secondary

Measure	Time frame
1. Postoperative multi organ failure 2. Postoperative infections 3. Length of hospital stay 4. Costs/benefits of universal leukocyte depletion for the Dutch health care 5. Role of perioperative medication Follow up : 1. Long term survival 2. Cancer recurrence in GI patients 3. Predictive role of cytokines and related genes	—

Countries

Netherlands

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026