Infertility in females aged between 36 and 42 years Urological and Genital Diseases Female infertility
Conditions
Interventions
Patients will be randomised on the day of ovum pick up by a independent operator to:
1. Blastocyst transfer:
1.1. Ovarian stimulation by agonist or antagonist protocol
1.2. Ovum pick up performed 36
Sponsors
GENERA Centre for Reproductive Medicine (Italy)
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Female patients aged between 37 and 42 years undergoing an IVF/ICSI attempt at the GENERA centre for Reproductive Medicine in Rome 2. History of less than 3 failed IVF/ICSI cycles 3. =6 MII retrieved 4. Signed consent form
Exclusion criteria
Exclusion criteria: 1. Woman younger than 37 years and older than 42 years 2. Positive serology for Hepatitis B, C or HIV 3. Diminished ovarian reserve: early follicular serum FSH > 10 IU/l and/or poor response during earlier COH/IVF or COH/ICSI (less than 6 follicles) 4. Persisting ovarian cysts > 30 mm diameter 5. Severe male factor infertility (Azoospermia)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cumulative live birth rate after blastocyt or cleavage stage strategy including pregnancies from fresh + cryoembryos transferred within 6 months after the end of the treatment | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Delivery rate per transfer 2. Multiple pregnancy rate 3. Pregnancy/childbirth: all women will be contacted to ask information on the delivery and on the health of the child: week of delivery, weight of the child, major and minor malformation 4. Time to pregnancy: the time to obtain the pregnancy from ovum pick up | — |
Countries
Italy
Outcome results
None listed