Primary prevention of infertility. Nutritional, Metabolic, Endocrine
Conditions
Interventions
The trial will be a two-group parallel randomized single-blind intervention study of 14 weeks duration that will be performed on healthy subjects (18-40 years) who, at baseline, followed a Western-sty
or 2) following the usual Western-style diet (control group).
Sponsors
Instituto de Salud Carlos III
Eligibility
Sex/Gender
Male
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1. Healthy subjects 2. Aged 18-40 years 3. Male 4. Follow a Western-style nutritional pattern
Exclusion criteria
Exclusion criteria: 1. Allergy to foods typical of the Mediterranean diet (nuts or traces thereof, extra virgin olive oil). 2. Presence of alcoholism, active drug dependence, or smoking (>5 cigarettes per day or equivalent). 3. Known history of hepatitis B or C, or HIV antibodies. 4. Any serious illness. 5. Cancer diagnosed within the last five years. 6. Active infectious disease. 7. High-grade inflammatory disease. 8. Scheduled surgery within the next 2 months after randomization. 9. Use of plant sterols, antihypertensive or antidiabetic medications, mineral supplements, fiber supplements, fish oil, or antioxidants. 10. Following vegetarian, macrobiotic, vegan, or similar diets for weight loss at the start of the study. 11. Weight loss of more than 5 kg in the past month. 12. Any type of disease in the reproductive history or vasectomy. 13. Use of medications associated with sperm abnormalities: antidepressants (paroxetine, citalopram, fluoxetine, sertraline, bupropion); calcium channel blockers (diltiazem, nifedipine); alpha-adrenergic blockers (tamsulosin, alfuzosin); antiepileptics (phenytoin, carbamazepine, valproate); antiretrovirals (HAART, saquinavir), etc. 14. Other medical or social conditions that may hinder adherence to the intervention or follow-up.
Countries
Spain
Contacts
Public ContactAlbert Salas Huetos
Outcome results
None listed