Major depressive disorder and alcohol use disorder Mental and Behavioural Disorders
Conditions
Interventions
Study 1:
Experimenters use a computer to create a series of random number sequences. These numbers are used to designate which treatment group a participant enters. Odd numbers indicate active rTMS gr
left dlPFC stimulation at 20 Hz, also at 100% RMT, delivered in trains of 10 pulses with 2 second inter-train intervals, totaling 1500 pulses over 6 minutes. For sham rTMS, the same stimulation protoc
Sponsors
Affiliated Psychological Hospital, Anhui Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Depressed participants: 1. Aged 18-60 years 2. Normal hearing, normal vision or normal corrected vision 3. Right-handed 4. Have received a stable dose of medication for more than 1 month 5. Diagnosed with a depressive disorder according to the International Classification of Diseases, 10th edition (ICD-10) diagnostic criteria Healthy participants: 1. Age 18-60 years 2. Normal hearing, normal or corrected vision 3. Right-handed 4. No previous diagnosis of mental or psychological illness 5. No history of major physical illness Alcohol addiction patients: 1. Aged 16-70 years old 2. Gender: Unrestricted 3. Currently receiving inpatient alcohol abstinence treatment 4. Voluntarily participate in the study and sign the informed consent form 5. Meet the ICD-10 diagnostic criteria for alcohol dependence syndrome 6. Post-acute withdrawal phase (14-30 days after cessation), with no significant withdrawal symptoms (CIWA-Ar score <7 points, MMSE =26 points) 7. At least 1 year of continuous alcohol use prior to systematic abstinence treatment 8. Normal vision, color vision, and hearing 9. Right-handed
Exclusion criteria
Exclusion criteria: 1. Cardiovascular and neurological diseases 2. History of head trauma with loss of consciousness 3. Physical anomalies 4. History of epilepsy 5. Pregnancy or breastfeeding 6. Treatment with electroconvulsive therapy 7. History of syncope 8. Currently participating in other research projects 9. Unwilling or unable to complete the entire experimental procedure Exclusion criteria for alcohol addiction: 1. Contraindications to TMS, MRI, and EEG (such as metal implants in the head, claustrophobia, etc) 2. Pregnant or lactating women, or women of childbearing age who are planning to become pregnant 3. Severe/uncontrollable systemic diseases (such as respiratory, circulatory, digestive, nervous and other systemic diseases) or mental illness (severe depression, schizophrenia, etc) 4. Other types of substance or non-substance addiction 5. Unable to sign the informed consent form 6. Illiterate 7. Unable to cooperate in completing the experiment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Study 1: Electroencephalography (EEG) data acquired using an Event-Related Potential (ERP) system before and after treatment (within 2 weeks) Study 2: 1. Magnetic resonance imaging (MRI) data acquired using an MRI scanner before the intervention 2. Electroencephalography (EEG) data measured using an Event-Related Potential (ERP) system before and after the intervention Study 3: Brain hemodynamic activity (blood oxygenation) assessed using functional near-infrared spectroscopy (fNIRS) at baseline and after the intervention (within 1 week) | — |
Secondary
| Measure | Time frame |
|---|---|
| Study 1: 1. Depression severity measured using the Hamilton Depression Rating Scale (HAMD) at baseline and after treatment (within 2 weeks) 2. Anxiety severity measured using the Hamilton Anxiety Rating Scale (HAMA) at baseline and after treatment (within 2 weeks) 3. Psychological symptoms measured using the Symptom Checklist-90 (SCL-90) at baseline and after treatment (within 2 weeks) 4. Sleep quality measured using the Pittsburgh Sleep Quality Index (PSQI) at baseline and after treatment (within 2 weeks) 5. Positive and negative affect measured using the Positive and Negative Affect Schedule (PANAS) at baseline and after treatment (within 2 weeks) 6. Depression symptoms measured using the Zung Self-Rating Depression Scale (SDS) at baseline and after treatment (within 2 weeks) 7. Anxiety symptoms measured using the Zung Self-Rating Anxiety Scale (SAS) at baseline and after treatment (within 2 weeks) Study 2: 1. Alcohol craving measured using the Alcohol Craving Scale (ACS) at baseline (prior to intervention) 2. Alcohol use disorder severity measured using the Alcohol Use Disorders Identification Test (AUDIT) at baseline (prior to intervention) 3. Anxiety severity measured using the Hamilton Anxiety Rating Scale (HAMA) at baseline (prior to intervention) 4. Alcohol craving measured using the Penn Alcohol Craving Scale (PACS) at baseline (prior to intervention) Study 3: Reaction time and accuracy measured using an alcohol-related paradigm at baseline | — |
Countries
China
Contacts
Public ContactYaqun Chen
Outcome results
None listed