Lipid mediators of ultraviolet radiation (UVR) induced skin inflammation

Identifying the network of lipid mediators responsible for maintenance and resolution of ultraviolet radiation-induced skin inflammation

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN47896115

Enrollment

125

Registered

2011-10-20

Start date

2011-10-01

Completion date

Unknown

Last updated

2017-02-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Topic: Skin

Interventions

Omega-3 PUFA (Incromega EPA500TG - fish oil supplements rich in omega-3 PUFAs) administered at 4g daily for 3 months

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Healthy, human volunteers and patients with defined photosensitivity conditions. 2. Aged 18 - 60 years 3. Sun reactive skin type I - IV (white Caucasian) 4. Both male & female participants

Exclusion criteria

Exclusion criteria: 1. History of skin cancer 2. Taking photoactive or anti-inflammatory medication 3. Sunbathing, sunbed use or phototherapy in the past 3 months 4. Taking nutritional supplements containing polyunsaturated fatty acids (PUFA) 5. Consuming more than 2 portions of oily fish per week 6. Pregnancy 7. Unable to eat fish or gelatine

Design outcomes

Primary

Measure	Time frame
Concentration of bioactive lipids in skin samples following UVR exposure measured at 3 months	—

Secondary

Measure	Time frame
1. Number of infiltrating inflammatory/immune cells during and until resolution of UVR induced inflammation measured at 3 months 2. The expression of key bioactive lipid metabolising enzymes and receptors in human skin measured at 3 months	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026