Hyperemesis gravidarum Pregnancy and Childbirth Excessive vomiting in pregnancy
Conditions
Interventions
Comparison of conventional inpatient continuous intravenous rehydration for women with HG with daily attendance at the Acute Gynaecology Unit for rehydration over four hours. The same anti-emetic and
Sponsors
St George's Healthcare NHS Trust (UK)
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: All pregnant women up to 20 weeks gestation referred to the Acute Gynaecology Unit with persistent vomiting and at least 1+ ketonuria.
Exclusion criteria
Exclusion criteria: 1. Women greater than 20 weeks gestation 2. Women with another medical condition manifesting as nausea and vomiting such as urinary tract infection (UTI) 3. Type 1 or 2 diabetes 4. Potassium less than 3.2 mmol/l 5. Sodium less than 130 mmol/l 6. Abnormal liver function tests (associated with increased severity of HG) 7. Abnormal thyroid function tests (associated with increased severity of HG)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| A difference between the two groups in reduction in Pregnancy-Unique Quantification of Emesis (PUQE) score at 48 hours. | — |
Secondary
| Measure | Time frame |
|---|---|
| A difference between the two groups in: 1. Number of days intravenous fluid treatment needed 2. Number with ketonuria at 48 hours 3. Improvement, at two and seven days from start of treatment, in: 3.1. PUQE 3.2. Drinking and eating scores 3.3. Well-being rating 4. Weight change at seven days 5. Number still taking anti-emetics at one week following discharge 6. Re-attendance episodes for hyperemesis in the seven days following discharge 7. Costs of treatment | — |
Countries
United Kingdom
Outcome results
None listed