Association of the type of antibiotics used at the time of appendix removal in children with appendicitis with wound infections after the surgery

Association between perioperative prophylaxis with cefuroxime plus metronidazole or amoxicillin/clavulanic acid and surgical site infections in pediatric appendectomy: a Swiss retrospective cohort study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN47727811

Enrollment

3839

Registered

2023-02-23

Start date

2014-01-01

Completion date

Unknown

Last updated

2023-10-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Children undergoing appendectomy for uncomplicated appendicitis Surgery

Interventions

The study only analyses data available through mandatory routine surveillance in Switzerland. All children up to the age of 16 years who have had their appendix removed for uncomplicated appendicitis

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients up to 16 years of age undergoing appendectomy for uncomplicated appendicitis in the study period from 2014 to 2018 in Switzerland

Exclusion criteria

Exclusion criteria: 1. Older than 16 years of age 2. Appendectomy carried out for complicated appendicitis (perforated, established abscess) 3. Receipt of antibiotics for perioperative prophylaxis other than the two target regimens 4. No perioperative antibiotic prophylaxis applied 5. Patients with missing procedure-related data

Design outcomes

Primary

Measure	Time frame
Surgical site infections (SSIs) up to 30 days after appendectomy as captured within the Swiss national SSI surveillance programme	—

Secondary

Measure	Time frame
There are no secondary outcome measures	—

Countries

Switzerland

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 10, 2026