Obsessive-compulsive disorder Mental and Behavioural Disorders
Conditions
Interventions
Participants will undergo three study visits on different days. On day 1 (total duration of 120 minutes) informed consent is signed and participants will undergo psychiatric diagnostic interviews / qu
Sponsors
Zon MW
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients: 1. Diagnosis of OCD with obsessions and compulsions assessed with the MINI Neuropsychiatric Interview (MINI) 2. Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) score cut-off of 12 3. 18-65 years of age 4. Willingness and ability to give written informed consent and willingness and ability to understand, to participate and to comply with the study requirements Controls: 1. 18-65 years of age 2. Willingness and ability to give written informed consent and willingness and ability to understand, to participate and to comply with the study requirements
Exclusion criteria
Exclusion criteria: Patients: 1. Current major depressive disorder, bipolar disorder, psychotic disorder, alcohol or substance dependence, or any cognitive disorder as assessed with the MINI 2. Major head trauma or neurological disease, current or in history 3. MRI contraindications such as metal implants, claustrophobia, left-handedness, pregnancy 4. Self-reported inability or unease to cease smoking for 3 hours prior to testing 5. Endocrinological disorders or regular use of corticosteroids 6. Current treatment with antipsychotic medication 7. Use of other psychotropic medication (apart from SSRI's or tricyclic antidepressant), or of recreational drugs over a period of 72 hours prior to each test session, and use of alcohol within the last 24 hours before each measurement 8. Irregular sleep/wake rhythm (e.g., regular nightshifts or cross timeline travel). Controls: 1. Current or past psychiatric diagnosis as assessed with the MINI 2. Major head trauma or neurological disease, current or in history 3. MRI contraindications such as metal implants, claustrophobia, pregnancy 4. Self-reported inability or unease to cease smoking for 24 hours prior to testing 5. Endocrinological disorders or regular use of corticosteroids 6. Use of psychotropic medication, or of recreational drugs over a period of 72 hours prior to each test session, and use of alcohol within the last 24 hours before each measurement 7. Irregular sleep/wake rhythm (e.g., regular nightshifts or cross timeline travel).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Whether stress facilitates a shift from goal-directed to habitual behaviour measured using behavioral data from a two-step sequential choice task that differentiates between model-free (habitual) and model-based (goal-directed) behavioral strategies. 2. Subjective anxiety ratings on a self-rating scale in response to visual OCD-related, general fearful and neutral stimuli. 3. Brain activity during at rest and during tasks measured using fMRI voxel-based signal covariation with task parameters. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Whether stress results in heightened amygdala response to biologically salient stimuli fMRI voxel-based signal covariation with task parameters. 2. How stress affects the functional integrity of the goal-directed and habit networks measured using a seed-to-voxel analysis. 3. Structural integrity of the implicated neural networks as measured with DTI tractography 4. Individual attachment style measured with the Adult Attachment Interview (semi-structured interview) and Experiences in Close Relationships scale (self-report scale) | — |
Countries
Netherlands
Contacts
Public ContactWieke van Leeuwen
Outcome results
None listed