Decreased time on mechanical ventilation when comparing analgesia-based sedation using remifentanil versus standard hypnotic-based sedation for up to 10 days in intensive care unit patients: a randomised trial.

Conditions

Medical or surgical patients requiring intensive care. Surgery Medical or surgical patients requiring intensive care.

Hao GW, Wu JQ, Yu SJ, Liu K, Xue Y, Gong Q, Xie RC, Ma GG, Su Y, Hou JY, Zhang YJ, Liu WJ, Li W, Tu GW, Luo Z.

2024-09-181 citations

Efficacy, safety, and pharmacokinetics of MR13A11A, a generic of remifentanil, for pain management of Japanese patients in the intensive care unit: a double-blinded, fentanyl-controlled, randomized, non-inferiority phase 3 study.

Doi M, Takahashi N, Nojiri R, Hiraoka T, Kishimoto Y, Inoue S, Oya N.

2023-11-137 citations

10.1186/s40560-023-00698-9

Long-term sedation with remimazolam besylate versus propofol in critically ill patients during invasive mechanical ventilation: a study protocol for a multicenter randomized non-inferior trial

Xiaobo Yang, Yun Tang, Ruofei Du, Yu Yuan, Jiqian Xu et al. (11 authors)

Frontiers in Pharmacology2023-07-285 citations

10.3389/fphar.2023.1139872

Enteral vs. intravenous ICU sedation management: study protocol for a randomized controlled trial.

Mistraletti G, Mantovani ES, Cadringher P, Cerri B, Corbella D, Umbrello M, Anania S, Andrighi E, Barello S, Di Carlo A, Martinetti F, Formenti P, Spanu P, Iapichino G, SedaEN investigators.

2013-04-0313 citations

10.1186/1745-6215-14-92

Efficiency and safety of inhalative sedation with sevoflurane in comparison to an intravenous sedation concept with propofol in intensive care patients: study protocol for a randomized controlled trial.

Soukup J, Selle A, Wienke A, Steighardt J, Wagner NM, Kellner P.

2012-08-1012 citations

10.1186/1745-6215-13-135

Cost-consequence analysis of remifentanil-based analgo-sedation vs. conventional analgesia and sedation for patients on mechanical ventilation in the Netherlands.

Al MJ, Hakkaart L, Tan SS, Bakker J.

2010-11-0125 citations

10.1186/cc9313

Effect of dexmedetomidine versus lorazepam on outcome in patients with sepsis: an a priori-designed analysis of the MENDS randomized controlled trial.

Pandharipande PP, Sanders RD, Girard TD, McGrane S, Thompson JL, Shintani AK, Herr DL, Maze M, Ely EW, MENDS investigators.

2010-03-16256 citations

10.1186/cc8916

Interventions

Comparing analgesia-based sedation using remifentanil versus standard hypnotic-based sedation for up to 10 days in intensive care unit patients. Titration of analgesia/sedation to achieve optimal seda

Eligibility

Inclusion criteria

Inclusion criteria: Critically ill patients requiring 3-10 days of mechanical ventilation.

Exclusion criteria

Exclusion criteria: Not provided at time of registration

Design outcomes

Primary

Measure	Time frame
Not provided at time of registration	—

Secondary

Measure	Time frame
Not provided at time of registration	—

Countries

Austria, Belgium, Denmark, France, Germany, Greece, Iran, Netherlands, Portugal, United Arab Emirates

Outcome results

None listed