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Analyzing the impact of injecting platelet-rich plasma on molar tooth movement

Evaluating the injection of platelet-rich plasma on second lower molars protraction: a randomized controlled clinical trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN47495953
Enrollment
18
Registered
2024-03-26
Start date
2020-09-01
Completion date
Unknown
Last updated
2025-09-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients with bilaterally extracted mandibular first molars Oral Health

Interventions

Patients were randomly allocated in a split-mouth study design to receive PRP injections on one side (PRP group) immediately before the start of protraction, while the other side received only saline
initially, the blood was centrifuged at 1600 rpm for 4 minutes to separate the plasma containing the platelets from the red cells. The plasma was drawn off the top and centrifuged for an additional 6

Sponsors

University of Aleppo
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Aged between from 17 and 25 years 2. Have all lower permanent teeth present, including intact third molar, but the bilateral first permanent lower molar were extracted and indicated mandibular second molars protraction, in which extractions were done at least one year ago to ensure complete extraction socket cortication and at most 3 years to avoid severely inclined second lower molars, or severely reduced alveolar bone height and width

Exclusion criteria

Exclusion criteria: 1. Have undergone previous orthodontic treatment 2. Have poor oral hygiene 3. Systemic disease especially those with coagulation problems or who are being treated with anticoagulants and NSAIDS 4. Unilateral chewing or extra-functional habits.

Design outcomes

Primary

MeasureTime frame
Rate of molar protraction from the beginning of protraction and the end of the seventh month, using a digital gauge

Secondary

MeasureTime frame
Type of movement of second molar protraction by lateral cephalometric images before molar protraction (T0) and after seven months of molar protraction (TF)

Countries

Syria

Contacts

Public ContactAmer Khatib
khateeb_485@alepuniv.edu.sy+963 992452493

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026