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The SYMPTOM Study: factors influencing patient appraisal of symptoms

Factors influencing patient appraisal of symptoms and associations with cancer diagnosis: an observational cohort study with an interview component

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ISRCTN
Registry ID
ISRCTN47493581
Enrollment
7000
Registered
2011-03-03
Start date
2010-11-22
Completion date
Unknown
Last updated
2019-02-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Topic: National Cancer Research Network, Primary Care Research Network for England

Interventions

1. Participant interviews: in-depth semi-structured interviews with approximately 120 participants 2. Questionnaires: questionnaires for self-completion will be mailed to the participa

Sponsors

Cambridge University Hospitals NHS Foundation Trust and University of Cambridge (UK)
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Respiratory symptoms: 1. Aged over 40 years, either sex 2. Persistent or changed cough 3. Change of breathlessness 4. Chest pain (intermittent, worse when breathing or coughing) 5. Coughing up blood-stained phlegm (haemoptysis) 6. GP expressed concern about possibility of cancer Gastrointestinal symptoms: 1. Aged over 40 years, either sex 2. Change in bowel habit 3. Blood in stool 4. Abdominal pain with weight loss 5. Abdominal mass 6. Anaemia 7. GP expressed concern about possibility of cancer

Exclusion criteria

Exclusion criteria: Respiratory symptoms: 1. Review of established diagnosis where there is no cancer concern 2. Previous lung or ENT cancer Gastrointestinal symptoms: 1. Review of established diagnosis where there is no cancer concern 2. Previous gastrointestinal (GI) cancer 3. Chronic alcohol abuse (to exclude chronic pancreatitis) 4. Known infective diarrhoea (e.g., after recent foreign travel) 5. Abdominal pain in the absence of weight loss 6. Dyspepsia 7. Upper abdominal pain where dyspepsia is a significant symptom

Design outcomes

Primary

MeasureTime frame
Identification of patient and symptom factors associated with later presentation to health care, measured at 24 months (end of study)

Secondary

MeasureTime frame
1. Association of delay in presentation of symptoms with stage at diagnosis, measured at 24 months (end of study) 2. Understanding patient interpretation of symptoms and the language used by patients, measured at 24 months (end of study)

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026