Investigation of enzymes in gingival crevicular fluid (GCF) and their gene activation profiles during orthodontic treatment

Pulp molecular and gingival crevicular fluid (GCF) enzymological profiles during orthodontic treatment

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN47483728

Enrollment

Registered

2008-08-14

Start date

2007-07-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Enzyme activity and gene profile during tooth movement Oral Health Dentofacial anomalies [including malocclusion]

Interventions

1. Assessment of the orthodontic appliance and evaluation of tooth movement at monthly interval (week 4, 8 and 12). The whole orthodontic treatment will be monitored clinically over 2 years. 2. Chara

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Both males and females, age range 14-30 years 2. Need for orthodontic treatment 3. Good general and periodontal health 4. Not pregnant 5. No use of antiinflammatory drugs, antibiotics or chlorhexidine mouthwash before and during study

Exclusion criteria

Exclusion criteria: 1. Patient had periodontal disease 2. Poor oral hygiene 3. Have many missing teeth prior to study

Design outcomes

Primary

Measure	Time frame
Activity of the enzymes and genes involved during orthodontic treatment will be identified.	—

Secondary

Measure	Time frame
Potential enzymes and genes for biomarkers will be determined (biomarkers that are involved in tooth movement i.e inflammation, bone formation, bone resorption).	—

Countries

Malaysia

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026