Soil-transmitted helminth infections (Ascaris lumbricoides, Trichuris trichiura, hookworms) Infections and Infestations Other helminthiases
Conditions
Interventions
Stool collection will be carried out for baseline parasitological assessment (two stools/participant, each stool tested for the presence of helminth eggs by the Kato-Katz [2 slides/stool] and FLOTAC m
Sponsors
Swiss Tropical Institute (STI) (Switzerland)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age: greater than or equal to 5 years old 2. Sex: males and females 3. Residency: resident of Nongyang village in Menghai county, Yunnan province, People?s Republic of China 4. Registration, participation: signing of written informed consent sheet (5 - 17 year olds: additional written approval by parents or legal guardians), willingness to comply with study procedures (stool submission, drug treatment, alcohol abstinence at day of treatment) 5. Absence of systemic or chronic diagnosed or perceivable illness as assessed by medical personnel upon enrolment and again at each day of treatment 6. Females: not pregnant (as verbally assessed by female medical personnel upon enrolment and again at each day of treatment)
Exclusion criteria
Exclusion criteria: 1. Age: less than 5 years 2. Residency: not a permanent resident of Nongyang village in Menghai county, Yunnan province, People?s Republic of China 3. Registration, participation: no written informed consent sheet signed or parental approval not obtained, unwillingness to comply with all study procedures 4. Presence or suspicion of any abnormal medical condition which is known or suspected to interfere with anthelminthic treatment 5. Known hypersensitivity to any anthelminthic drugs 6. Recent history of anthelminthic treatment 7. Current or past (within 1 month) participation in any other medical trial 8. For females: suspected or verified pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cure rates of single-dose and triple-dose oral albendazole and mebendazole for treating common soil-transmitted helminth (STH) infections, especially hookworms, assessed at 2 - 3 weeks post-treatment. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Safety of single-dose and triple-dose oral albendazole and mebendazole against common STH infections 2. Egg-reduction rates of single-dose and triple-dose oral albendazole and mebendazole against common STH infections Assessed at 2 - 3 weeks post-treatment. | — |
Countries
China
Outcome results
None listed