Early neonatal sepsis in preterm infants Neonatal Diseases
Conditions
Interventions
Intervention Group (Early EBM + Maternal-Incubator Care):
1. Initiate total nasogastric feeding with EBM within 3 hours of birth (60–80 mL/kg/day)
2. No IV fluids or antibiotics unless clinically indi
Sponsors
Bacha Khan Medical Complex MTI Swabi
Eligibility
Sex/Gender
All
Age
0 Days to 1 Days
Inclusion criteria
Inclusion criteria: 1. Gestational age >30 and 1000 g 3. Clinically stable at birth: Apgar =7 at 5 minutes or no need for invasive ventilation 4. Minimal respiratory support allowed: room air or oxygen =2 L/min via nasal cannula 5. No major congenital anomalies 6. Mother is stable and can take care for newborn
Exclusion criteria
Exclusion criteria: 1. Need for immediate resuscitation or mechanical ventilation 2. Clinical signs of sepsis at birth (e.g., temperature instability, poor perfusion, metabolic acidosis) 3. Prolonged rupture of membranes >18 hours with maternal chorioamnionitis or other high-risk infections 4. Maternal fever >38°C during labor or proven maternal sepsis 5. Major surgical conditions or gastrointestinal malformations 6. Reverse diastolic flow on prenatal ultrasound 7. Maternal death
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Measured using patient records at end of stay: 1. Time to achieve full enteral feeding 2. Weight gain at discharge 3. Duration of hospital stay 4. Maternal satisfaction (via structured questionnaire) 5. Cost-effectiveness in terms of hospital stay, antibiotics use, incubator and NICU charges | — |
Countries
Pakistan
Contacts
Public ContactWaqar Ahmad
Outcome results
None listed