Overweight, obesity Nutritional, Metabolic, Endocrine Obesity
Conditions
Interventions
Supervised exercise to expend 500 kcal 5 times/week for 12 weeks. Assessments at week 0, week 6 and week 12. No exercise overweight/obese and lean comparators.
Sponsors
University of Leeds (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. 18 - 55 years old 2. Sedentary lifestyle (no leisure-time physical activity in previous 6 months) 3. Body Mass Index (BMI) between 27 - 38 kg/m2 or 18 - 23 kg/m2 (lean control) 4. Signed consent given 5. No objection from participant's GP
Exclusion criteria
Exclusion criteria: 1. Inability to fully comply with intervention or study procedures 2. Insufficient English language skills to complete all questionnaires 3. Pre-existing injuries or conditions that could be aggravated by regular physical activity 4. Medication that could influence accumulation or expenditure of energy 5. Cardiac problems (arrhythmia, Congestive heart disease) 6. Uncontrolled hypertension 7. Genetic syndromes associated with obesity 8. Presence of untreated hypothyroidism 9. Recent body weight change (± 2 kg in previous 3 months) 10. Currently following weight loss regime 11. Food allergies or aversions
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Study 1: Change in energy balance from week 0 to week 12 measured by the product of the energy cost of a unit change in fat mass by the observed change in fat mass and summing it with the product of the energy cost of a unit change in lean mass by the observed change in lean mass. Study 2: Rise and fall in concentration of gut peptides assayed from the participants? blood samples in the four hour period following consumption of breakfast. | — |
Secondary
| Measure | Time frame |
|---|---|
| Study 1: 1.1. Cardiovascular fitness at week 12 will be measured by VO2 maximal test of aerobic capacity 1.2. Resting heart rate and Blood pressure at week 12 will be measured by an integrated digital blood pressure and heart rate monitor with inflatable cuff 1.3. Resting metabolic rate at week 12 will be measured by Gas Exchange Measurement 1.4. Substrate oxidation at week 12 will be measured by indirect calorimetry 1.5. Eating behaviour at week 12 will be measured by intake of test meals designed to vary in macronutrient composition (20:65:15 and 35:50:15, % carbohydrate:fat:protein) and quantitative ratings of hunger and satiety by questionnaire Study 2: Quantitative ratings of hunger and satiety by questionnaire. | — |
Countries
United Kingdom
Outcome results
None listed