Stage II to III colorectal cancer survivors Cancer Colorectal
Conditions
Interventions
Participants will be randomized into either an exercise or usual care group via minimization method.
1. The exercise group will receive a 12-week home-based exercise program. They will
Sponsors
Yonsei University College of Medicine (South Korea)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Between 18 and 75 years of age 2. Histologically confirmed stage II to III colorectal cancer 3. Completed surgery, radiotherapy, and/or chemotherapy within 4-104 weeks prior to the study 4. ECOG performance status of 0 of 1 5. Not planning extended absences in the 3 months subsequent to enrollment
Exclusion criteria
Exclusion criteria: 1. Existing evidence of recurrent or metastatic disease 2. Participation in regular physical activity (purposeful activity of at least a moderate intensity of 200 minutes or more a week) 3. Pregnant or planned to be pregnant within 6 month
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Level of fasting insulin will be measured by a chemiluminescence immunoassay 2. Adiponectin levels will be measured by an enzyme immunoassay kit 3. Insulin resistance will be estimated using the homeostatic model assessment of insulin resistance (HOMA-IR) index | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. hs-CRP will be measured by a latex-enhanced immunoturbidimetric assay using an ADNIA 1650 Chemistry system 2. TNF-a levels will be measured using a commercially available enzyme-linked immunosorbent assay 3. Chemerin levels will be measured by an enzyme immunoassay kit 4. Levels of fasting glucose, AST, ALT, GGT, TC, TG, HDL-C will be measured using an ADVIA 1650 Chemistry system 5. Physical fitness measured by the 30minute step test, 6-min walk test, chair stand and push up test 6. Quality of life measured by the FACT-C questionnaires | — |
Countries
Korea, South
Outcome results
None listed