The use of metformin in patients with polycystic ovarian syndrome requiring treatment with in vitro fertilisation (IVF)

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN47219228

Enrollment

100

Registered

2003-09-12

Start date

2003-01-01

Completion date

Unknown

Last updated

2016-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Urological and Genital Diseases: Polycystic ovarian syndrome (PCOS) Urological and Genital Diseases Polycystic ovarian syndrome (PCOS)

Interventions

Group A will be given 500 mg metformin TDS for 1 month prior to their treatment. Group B will not be treated with metformin. Both groups will undergo standard IVF treatment.

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Patients with PCOS

Exclusion criteria

Exclusion criteria: Does not meet inclusion criteria

Design outcomes

Primary

Measure	Time frame
1. Total number of folicles reaching 18 mm 2. Number of eggs obtained, number and quality of mature eggs, fertilisation rates 3. Total number of embryos, number and quality of embryos replaced and number of embryos frozen 4. Biochemical pregnancies, clinical pregnancies 5. Number of cycles abandoned for poor response and over response 6. Number of cases of ovarian hyperstimulation in each group	—

Secondary

Measure	Time frame
Not provided at time of registration	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026